ISSN 1662-4009 (online)

ey0016.7-6 | Genetics of Puberty | ESPEYB16

7.6. Elucidating the genetic architecture of reproductive ageing in the Japanese population

M Horikoshi , FR Day , M Akiyama , M Hirata , Y Kamatani , K Matsuda , K Ishigaki , M Kanai , H Wright , CA Toro , SR Ojeda , A Lomniczi , M Kubo , KK Ong , JRB Perry

To read the full abstract: Nat Commun. 2018 May. 17;9(1):1977.This population study reports 26 loci for ages at menarche and menopause in a Japanese population and demonstrates widespread differences in allele frequencies and effect estimates between Japanese and European variants.Over the past decade, genome-wide association study (GWAS) meta-analys...